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Covaxin doses 50% effective against symptomatic Covid: Real-world study

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Two doses of Covaxin, the India-made vaccine, are 50 per cent effective against symptomatic Covid-19, said an independent study by researchers based on real-world assessment .


Results of the interim study, which was published in The Lancet Infectious Diseases Journal, showed that two doses of the vaccine manufactured by Bharat Biotech Covaxin, also known as BBV152, had 77.8 per cent efficacy against symptomatic disease and present no serious safety concerns..





The study titled ‘Effectiveness of an inactivated virus-based SARS-CoV-2 vaccine, BBV152, in India: a test-negative, case-control study’ assessed 2714 hospital workers at the All India Institute of Medical Sciences (AIIMS) in Delhi, from April 15–May 15, who were symptomatic and underwent RT-PCR test for Covid-19 detection.


The researchers, including doctors Manish Soneja, Adil Rashid Khan, Devashish Desai, Ankit Mittal and others, said that they received no funding for the study and protocol for it was approved by AIIMS ethics committee.


Researchers also noted that the Delta variant was the dominant strain in India during the period of the study. At that time, the Delta variant approximately accounted for 80 percent of all confirmed Covid19 cases.


Of the 2,714 employees in the study population, 1,617 people tested positive for SARS-CoV-2 infection, the virus that causes COVID-19, and 1,097 tested negative.


Researchers evaluated the effectiveness of the vaccine against symptomatic RT-PCR confirmed SARS-CoV-2 infection. The study found that the vaccine effectiveness against symptomatic Covid-19 after two doses of Covaxin with the second dose administered 14 or more days before undergoing RT-PCR testing was 50 per cent. The researchers also added that effectiveness remained stable over the seven-week follow up period.


“The vaccine effectiveness estimated in our study is lower than the efficacy announced after completion of the phase 3 trial, despite a similar testing strategy being used (SARS-CoV-2 RT-PCR testing for participants with symptoms suggestive of COVID-19 determined through weekly telephone follow-up),” the researchers noted in the study.


They reasoned that several factors might be responsible for the observation of a lower effectiveness in this study.


“First, the population included in our study comprised only hospital employees, who might have been exposed to a higher risk of SARS-CoV-2 infection than the general population,” the said. The research was conducted during the peak of India’s second wave of COVID-19 with high test positivity rates for both hospital employees and residents of Delhi, they said. “On April 26, 2021, the test-positivity rate for Delhi was around 35%, which was the highest it had been since the beginning of the pandemic,” the researchers noted.


“Thus, our results might only reflect the performance of BBV152 under such surge conditions,” they added.


The prevalence of circulating variants of concern, especially the delta variant, might have contributed to lower effectiveness of BBV152.


“Although in-vitro studies have shown neutralisation of these variants by both convalescent and post-vaccine sera, the neutralisation titres are several times lesser against variants, particularly the delta variant,” the study noted.


The phase 3 trial of BBV152 was conducted during a period when the overall test-positivity rate was low, and the prevalence of the delta variant among positive cases was largely unknown.


“By contrast, at the end of April, 2021, a period during which this study was conducted, the delta variant was the dominant strain, making up more than 80% of all sequenced genomes as per the reports from the Indian SARS-CoV-2 Genome Sequencing Consortia,” the authors noted.


The researchers acknowledged several limitations to their study. It does not estimate the vaccine effectiveness against hospitalisation, severe disease, and death, which require further assessment, they noted. The study was not designed to estimate vaccine effectiveness for different time intervals after vaccination or to determine if vaccine effectiveness changed over time, they said.

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Americans Are ‘Sheep’ for Not Protesting COVID-19 Measures

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  • Donald Trump Jr. praised a recent wave of protests in Europe over new COVID-19 restrictions.
  • He told Fox News that Americans were “sheep” for not “pushing back.”
  • Trump Jr. also falsely claimed that the US media was suppressing reports about the European protests.

Donald Trump Jr. praised countries in Europe for protesting against COVID-19 restrictions and said American people were “sheep” for not doing the same.

The former president’s son made the comments while speaking to Fox News’s Dan Bongino on Saturday.

“Europe is pushing back, and America is sitting there like sheep. ‘Oh, this is great. We’ll just go along with what these guys who’ve gotten nothing right in the last two years tell us.’ It’s absolute insanity,” Trump Jr. said. 

 

Trump Jr. also falsely claimed that the media in the United States was deliberately not reporting on the recent wave of protests in Europe over COVID-19 winter restrictions, some of which turned into riots.

“You don’t hear about what’s going on as it relates to the riots in Europe on a daily basis now against the vaccine mandates because our media wants to block that out,” Trump Jr. said. 

“They’re going to make sure that you never hear about it because they don’t want you getting these kind of ideas that freedom may actually still exist in some parts of the world.”

Numerous major US news outlets, including The New York Times, Fox News, ABC News, and Insider, reported extensively on the European protests.

Several European countries have introduced new measures to combat the spread of COVID-19 as winter approaches, including lockdowns and proof of vaccination to access certain places.

Earlier this year, the US introduced requirements for federal employees to be vaccinated, removing the option to get routinely tested instead.

As Insider previously reported, similar vaccine mandates in Europe have proved to be successful in increasing uptake.

Research has shown that the US has much higher rates of vaccine hesitancy than most European countries.

In the same interview with Fox, Trump Jr. criticized President Biden for not completely curbing the spread of the virus and bizarrely criticized the president for not curing cancer.

“He was also going to cure cancer, if I remember correctly, Dan,” Trump Jr. told Dan Bongino. “Remember that? Everyone was, ‘Oh, that’s great, we should definitely elect him.’ I haven’t seen much movement on that.”

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Download Badass Monster Killer (2015) Dual Audio (Hindi-English) 480p [400MB] || 720p [800MB] – Moviesflix | Movies flix – TheMoviesFlix.com |Moviesflix | Movies flix

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On the trashy side of Camaroville, there’s a mob turf war going down, but the new gang in town ain’t content with merely controlling the local dope and sex trade. They are also mixed up with dangerous black magic, intent on resurrecting hideous demon-gods who have waited centuries for the chance to eat all our souls and enslave mankind! These blasphemous bad guys need.

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covid: Omicron fallout: Covid test at Chandigarh OPDs | Chandigarh News

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CHANDIGARH: The health department is on alert after the WHO confirmed omicron as a new Covid variant of concern. A list of travellers is being compiled with the help of the police to monitor and track them, while all public hospitals OPDs will again start testing patients for Covid.
Since the past four days, there has been a slight rise in the number of daily positive cases. On November 24, six cases were reported. The next day, nine positives were confirmed. On November 26, eight and on Saturday, five cases were detected. . The active cases have also increased from 35 on November 23 to 52 on Saturday.
“We daily review the Covid status and at intervals send samples for genome sequencing. However, the public must adhere to Covid appropriate behaviour as we are seeing mutations in those countries which had least vaccination,” said director health services Dr Suman Singh.

TimesView

The detection of the variant of concern, with cases popping up in many countries, calls for greater vigilance in the tricity. The increased surveillance of overseas travellers and strict adherence to Covid-appropriate behaviour, which has been junked by most people, is the only thing that will help in keeping things under control.

All states/ UTs have been told to adhere to the overarching ‘test-tracktreat-vaccinate’ principle to ensure stringent implementation of containment measures as per Centre guidelines.“While we have 73% coverage of full immunisation in the city and the antibodies against the virus was seen to be over 75% in the adult population, there is a belief that there is a need for booster dose in some sections of the population. Implying, the immunity is waning and if there is a mutant in any part of the world, it can affect our public health measures if we do not follow Covid appropriate behaviour,” said a public health expert.The administration has also issued an advisory, asking resident of the city to follow all the protocols. The residents are request to take all precautionary measure to phase out the pandemic. Chandigarh administration is also pushing hard for complete vaccination of residents.
AIRPORT SCAN
The UT administration has started monitoring people from abroad at the airport. Passengers are being categorised, with those from high-risk countries (South Africa, Brazil, Bangladesh, Botswana, China, Mauritius, New Zealand and Zimbabwe) being made to undergo RT-PCR test on their arrival and undergo quarantine for seven days. On the eighth day, they will be retested (RT-PCR) again.

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