BY JON KAMP | UPDATED 11月 21, 2021 08:00 午前 EST
A WSJ analysis of new data sharpens picture of who is likely to get serious infections after full vaccination, with age and underlying conditions key factors
Breakthrough cases of Covid-19 are hitting older people and those with underlying health conditions particularly hard, according to a new review of data by The Wall Street Journal that sharpens the picture of who remains at risk despite vaccinations.
State reporting is inconsistent but collectively shows there have been more than 1.89 million cases and at least 72,000 hospitalizations and 20,000 deaths among fully vaccinated people in the U.S. this year, the Journal found.
State and federal data broadly show unvaccinated people are primarily driving pandemic numbers. Breakthrough infections, however, are making up a growing portion because of rising numbers of vaccinated people and waning immunity among people who got their shots early on, some states show.
Spotty U.S. data have clouded the view of just how many fully vaccinated people are getting Covid-19, landing in hospitals and dying. The Centers for Disease Control and Prevention doesn’t publish a running tally on raw breakthrough numbers. The Journal reviewed medical-record data for a total of more than 21 million fully vaccinated people, and an array of state reports, to compile its analysis. In particular, people with diabetes, chronic lung disease, kidney disease and compromised immune systems were at risk of serious outcomes from breakthrough cases, the data show.
Health agencies generally define fully vaccinated as two weeks beyond a second mRNA vaccine or a single Johnson & Johnson shot.
Tracking breakthroughs is an important part of protecting vulnerable people as the nation shifts to managing Covid-19 for the long term, according to public-health officials. The effort includes stepping up boosters and improving overall vaccine uptake, public-health experts say.
“You have to be humble in the face of Covid,” said Sharon Balter, director of the division of communicable disease control and prevention for Los Angeles County’s public-health department. Her agency reported in August that unvaccinated people were nearly five times more likely to get Covid-19 and about 29 times more likely to be hospitalized than fully vaccinated people.
CDC Director Rochelle Walensky said Wednesday that emergency room visits by vaccinated people age 65 and older were increasing. “We want to reinforce the importance of people who are eligible getting boosted now,” Dr. Walensky said.
These people are often vulnerable. Recent data from South Carolina show 79% of people hospitalized with breakthrough infections there had at least one existing health condition, such as diabetes. In the intensive-care unit, where hospitals treat the most severely ill patients, the percentage increased to 88%.
At the Medical University of South Carolina, nearly all fully vaccinated Covid-19 patients in the ICU have weak immune systems from prior health problems, said Andrew Goodwin, the section chief of critical care. The rest are elderly, which can also compromise the body’s defense against illness.
Truveta Inc., a firm that aggregates hospitals’ medical data for research, found among 1.7 million fully vaccinated people that those with diabetes, chronic lung disease and chronic kidney disease were about twice as likely to be hospitalized for breakthrough cases as vaccinated people without these conditions.
The likelihood of having a breakthrough infection was still low, though confirmed infections were more common for people with these illnesses. About 1.5% of roughly 110,000 people with chronic kidney disease had one, for example. But Truveta found about a quarter of breakthrough patients with chronic kidney disease wound up hospitalized. The likelihood of hospitalizations for people with breakthrough cases but without underlying health problems was about 7.5%.
Breakthrough deaths are hitting older people the hardest, amplifying a well-worn pandemic pattern. Exclusive data the Journal reviewed from the Epic Health Research Network, which analyzes data from the medical-record software company Epic Systems Corp., shows about 80% of breakthrough deaths among the vaccinated are in people ages 65 and older. The data included records for 19.5 million fully vaccinated people. Among all Covid-19 deaths this year, that age group represents closer to 69%, according to the CDC.
The Epic Health Research Network data also point to more severe breakthrough cases in the most vulnerable patients, who were identified using a federal measure of social and economic factors. “This is magnifying underlying health disparities that we’re seeing,” said Harvard T.H. Chan School of Public Health researcher Thomas Tsai, co-author of a study that found the most-vulnerable communities had twice the odds of hospitals with ICUs near capacity than the least-vulnerable areas, using the same federal measure.
Data sets differ in how they count Covid-19 hospitalizations. Epic Health Research Network researchers included people with confirmed cases who were admitted to hospitals for Covid-19, while Truveta included Covid-19 positive people who might be hospitalized for other reasons.
The CDC’s breakthrough data reflect samples of the population from multiple sources, such as one network that collects data from 250 acute-care hospitals across 14 states and another that uses Department of Veterans Affairs records. The agency’s data show higher rates of cases, hospitalizations and deaths among the unvaccinated. Detailed reporting on breakthroughs by states is voluntary.
“CDC does not need to have data from all jurisdictions to be able to draw strong conclusions about disease trends,” the agency said.
The Epic Health Research Network’s cumulative data show about 1.2% of fully vaccinated people had a breakthrough case, similar to findings among states that publicize such data. The company also found a tipping point for breakthrough cases at about 20 to 22 weeks after people got their latest shot. Georgia found something similar while measuring the gap between when people became fully vaccinated and tested positive for Covid-19.
The findings seem to reflect factors including when vaccine effectiveness began to wane in many people and the rampant spread of the Delta variant in late summer, said Jackie Gerhart, a physician and vice president of clinical informatics at the Epic Health Research Network. Its data show breakthroughs climbed significantly during the Delta surge.
State officials have stressed that unvaccinated people remain at higher risk. In Vermont, which leads the states with 72% of its population fully vaccinated, unvaccinated people have recently made up roughly 70% of new cases, Health Commissioner Mark Levine said in an interview this month.
Authorities are concerned that vaccinated people are making up a bigger piece of the pie, however, and are urging boosters. On Thursday, Kentucky Gov. Andy Beshear noted that 16% of hospitalizations in that less-vaccinated state have been among fully vaccinated people since March 1. Last month the cumulative figure was 8.4%.
“Look at how these numbers have changed,” he said. “This is waning immunity.”
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Vistara resumes flights to Singapore amid concerns over new Covid-19 variant | Latest News India
The World Health Organisation has dubbed Omicron a variant of concern after early evidence showed it could be more transmissible, and resistant to immunity from past infection or vaccination
A Vistara flight from Mumbai landed in Singapore on Monday while Singapore Airlines and IndiGo were also scheduled to resume their flights between the two countries even as the airlines awaited clarity on operations in view of the detection of a new Covid-19 variant–Omicron.
The government on Friday allowed scheduled international flights from December 15 to and from all countries considered not at risk”. Prime Minister Narendra Modi on Saturday asked officials to review the plan to ease international travel restrictions after the new variant triggered global alarm. He called for the need to be “proactive in light of the new threat”.
The World Health Organisation has dubbed Omicron a variant of concern after early evidence showed it could be more transmissible, and resistant to immunity from past infection or vaccination. The detection has prompted countries such as Japan to suspend the entry of foreign visitors.
Also Read: Congress MP reminds Centre of promise to fully vaccinate Indians by 2021
Vistara operated the Mumbai-Singapore flight under the Vaccinated Travel Lane (VTL), which allows quarantine-free travel to Singapore for fully vaccinated travellers. The airline has scheduled five flights weekly to Singapore.
IndiGo was scheduled to operate a Chennai-Singapore flight under VTL at 2.50 pm. It has been allocated 3,618 seats per week, of which 1,624 seats will be available on the Chennai-Singapore route under VTL.
“The rest of the capacity will be utilised under non-VTL conditions for travel to and from Singapore,” an airline spokesperson said.
A Singapore airline official said they will be operating flights to Singapore as per schedule until the government issues fresh guidelines. The airline’s first flight between the two countries is scheduled to take off at 4.25 pm (IST) from Singapore and arrive in Delhi at 9.55 pm.
“They changed the character to suit me”
Ma Dong-seok has opened up about how he ended up being cast in the latest Marvel film, Eternals.
In a new interview with, the Korean-American actor – known for roles in South Korean movies such as Train To Busan, The Outlaws and more – spoke about what it was like to make his Hollywood debut in Eternals and the process which led him to being a part of the film.
“Train To Busan was a global sensation,” he said. “The people at Marvel watched me in The Outlaws, The Gangster, The Cop, The Devil and Champion and requested me for a casting.”
“After that, I was busy with my life until I received a phone call. It was [casting director] Sarah Finn saying, ‘There’s a character perfect for you in a Marvel movie called Eternals. Come take a look’,” he added, noting that he knew the character of Gilgamesh would be “perfect” for him.
Ma then spoke about how Eternals director Chloé Zhao and Marvel had worked together to modify the character for him. “In fact, Gilgamesh isn’t even an Asian character. They changed the character to suit me,” he said. “They knew that I had boxed for a long time, so they changed the action to hand-to-hand combat. I was really touched that they were so considerate and made the character to fit me.”
Elsewhere during the interview, the actor also touched on what being a South Korean actor in a Hollywood film meant for a global audience. “It’s no longer shocking for an Asian actor to be cast into a Hollywood film,” he said. “But I think my situation is unique because I’m taking on the role of an action hero.”
In other news, Zhao has spoken about why she cast Harry Styles in Eternals. “I kept tabs on Harry since Dunkirk, I thought he was very interesting,” she told. “After meeting him I realised he is that character – the same way I cast the rest of my cast.”
Rick And Morty Season 6 Release Date, Crossover- Daily Research Plot
Rick And Morty Season 6 Updates: Now it’s time to get schwifty. Season six of Rick and Morty is formally on its manner, with creators Dan Harmon and Justin Roiland tough at the artwork on the subsequent batch of episodes.
The active sci-fi collection has come to be a prime hit for the cause that its debut in 2013 and lovers are keen for his or her subsequent hit of wacky generation fiction action.
This sounds greater formal and a few human beings could probably say it is better.
But what’s going to appear to Rick and Morty in Season 6?
“Rick & Morty” added a hair-raiser withinside the Season five finale, with the Citadel destroyed andon his manner to a universe outdoor of Rick’s influence.
It’s the shape of the finale that really turns a display upside down, and we cannot wait to discover how Rick and Morty are going to deal with it.
Will they track down Evil Morty and position subjects properly, or has the multiverse been modified forever? Here’s what we recognize approximately Rick and Morty Season 6 so far:
“Rick and Morty” Season 6 is predicted to air on Adult Swim, however no unique beginning date has been announced.
It is presently unknown while the subsequent season will debut, however, it’s miles concept that the season will debut around 12 months after the season five finale.
In October 2022, the temperature can be a strong prediction. There has to turn out to be a one-12 months damage among Season four and Season five, so that is understandable.
Spencer Grammar discovered out that Season 6 is probably already withinside the works and may not take as extended to hit the air on our TVs.
This is the query this is left after the final season. With the destruction of the Citadel, Rick’s delivery of portal fluid has needed to have prolonged past up in smoke.
At the stop of the season five finale, Rick throws his portal gun away. Will portal generation artwork after the sports activities of this catastrophe?
Rick And Morty Season 6 Evil Morty
Season 6 really wants to solution this query quickly, It is likewise feasible that Evil Morty has spread out in fact new possibilities. Breaking the primary finite curvelets in Rick Sanchez to journey to vicinity wherein he is not the pinnacle dog.
Rick and Morty are headed to 1 of these one-of-a-type universes, and that is probably no longer going to stop well for our Rick and Morty.
It can be nearly now not viable for C-137 Rick to capture as a good buy as him if there’s no greater portal fluid to transport round. Season 6 goes to should solve some of the one’s questions if Rick and Morty are going to hold the multiverse.
Either that or way to the meta-humor of the display, the whole thing can be over again to every day the minute Season 6 kicks off. who knows.
By February 2021, “Rick and Morty” author Rubens tweeted that the group had started writing Season 7.
“Am I allowed to mention we started out writing Rick and Morty Season 7? That’s a quite proper indicator that the scripts for Season 6 had been completed.
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