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Chances of unborn baby contracting Covid-19 virus extremely limited: Study | Health
According to a study led by UCL researchers with Great Ormond Street Hospital for Children and the NIHR Great Ormond Street Biomedical Research Centre, it is only possible for an unborn baby to contract Covid-19 if their gut is exposed to the SARS-CoV-2 virus.
The research was published in the ‘BJOG – An International Journal of Obstetrics & Gynaecology Journal’.
Although the study did not look specifically at mothers with Covid-19 and whether their infection was transmitted to an unborn baby, it found that certain fetal organs, such as the intestine, are more susceptible to infection than others.
However, researchers said, that opportunities for the Covid-19 virus infecting the fetus are extremely limited, as the placenta acted as a highly effective and protective shield, and evidence suggested fetal infection, known as vertical transmission, is extremely uncommon.
Researchers set out to understand how newborn babies could have developed Covid-19 antibodies, as it had been reported in a small number of cases.
Specifically, they wanted to know if and how the virus could be passed from an infected mother to the unborn fetus.
To answer this question, researchers examined various fetal organs and placenta tissue to see if there was any presence of the cell surface protein receptors, ACE2 and TMPRSS2. These two receptors sit on the outside of cells and both are needed for the SARS-Cov-2 virus to infect and spread.
Researchers found the only fetal organs to feature both the ACE2 and TMPRSS2 were the intestines (gut) and the kidney; however, the fetal kidney is anatomically protected from exposure to the virus and is, therefore, less at risk of infection.
Therefore, the team concluded that the SARS-CoV-2 virus could only infect the fetus via the gut and through fetal swallowing of amniotic fluid, which the unborn baby does naturally for nutrients.
After birth ACE2 and TMPRSS2 receptors are known to be present in combination on the surface of cells in the human intestine as well as the lung. The gut and lung are suspected to be the main routes for Covid-19 infection, but in younger children, the intestine appeared to be most important for virus infection.
Senior author, Dr Mattia Gerli (UCL Division of Surgery and Interventional Science & the Royal Free Hospital) explained, “The fetus is known to begin swallowing the amniotic fluid in the second half of pregnancy. To cause infection, the SARS-CoV-2 virus would need to be present in significant quantities in the amniotic fluid around the fetus.”
“However, many studies in maternity care have found that the amniotic fluid around the fetus does not usually contain the SARS-CoV2 virus, even if the mother is infected with Covid-19. Our findings, therefore, explain that clinical infection of the fetus during pregnancy is possible but uncommon and that is reassuring for parents-to-be,” Gerli added.
The study, funded by the Medical Research Council (MRC) and UKRI Covid-19 rapid response initiative, provided the most definitive information, to date, regarding the susceptibility of the human fetus to Covid-19 infection.
Fetal organs and tissues were made available via the Human Developmental Biology Resource (HDBR) biobank, which assisted embryonic/fetal research. None of the organs and tissues from donated fetuses was from Covid-19-infected mothers and, in line with ethical guidelines, the research team did not test for Covid-19 antibodies.
Co-senior author Professor Paolo De Coppi (UCL Great Ormond Street Institute of Child Health and NIHR Great Ormond Street Hospital) said, “We have shown that the fetal intestine, which is in contact with amniotic fluids swallowed by the baby, is susceptible to SARS-CoV-2 virus. However, the placenta acts as a natural barrier, and with the limited evidence of amniotic fluid containing the virus, our study should provide reassurance to mothers.”
The authors highlighted that the biggest risk to the fetus during pregnancy is if the mother becomes very unwell with Covid-19 infection. In this instance, the virus may be present in high concentrations in the amniotic fluid. In addition, it could damage the placenta, which can lead to preterm birth.
Co-author, Professor Anna David (UCL Elizabeth Garrett Anderson Institute for Women’s Health and UCLH NIHR Biomedical Research Centre) added, “Vaccination against Covid-19 is known to be safe in pregnancy and reduces the chance of Sars-CoV2 infection to very low levels. The results of this study provide definitive information regarding the susceptibility of the human fetus to Covid-19 infection. Our findings support current healthcare policy that vaccination in pregnancy is the best way for mothers to protect their unborn baby from Covid-19 infection.”
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This story has been published from a wire agency feed without modifications to the text. Only the headline has been changed.
“Show Window: The Queen’s House” Cast Shares Key Points To Look Forward To Ahead Of Premiere
There’s only one day left until the premiere of Channel A’s new drama “”!
“Show Window: The Queen’s House” is a new drama about a woman who supports another woman’s affair—without knowing that the affair is with her own husband.will star as Han Sun Joo, the queen of her picture-perfect family, while will star as Shin Myung Seob, her seemingly devoted husband. will star in the drama as Yoon Mi Ra, who befriends Han Sun Joo while secretly carrying on an affair with her husband behind her back.
Lee Sung Jae commented, “The characters in ‘Show Window: The Queen’s House’ possess both truth and lies, as well as both good and evil. It will be interesting to watch their desperate struggle to keep the show window of the beautiful kingdom that they’re trapped in from breaking.”
He also asked drama fans to pay special attention to his character’s storyline as he added, “I hope you will also enjoy the process of deducing whether or not Shin Myung Seob will be able to create his own perfect kingdom.”
When Jun So Min was asked to name the drama’s key point of interest, she instead asked the question, “Do you like chess?” She then explained, “The drama will become more intriguing if you think of the personality and tendencies of each chess piece and relate them to the characters.” One example to support this analysis is Han Sun Joo, who is referred to as the queen of her family. Drama fans will have to figure out how the other characters relate to each other on the drama’s chessboard.
2PM’s, who plays Yoon Mi Ra’s younger brother Han Jung Won, pointed to his character’s own hidden strife as a key point of the drama. He shared, “There are plenty of enjoyable elements, so I think you’ll have fun yelling at the screen while you watch it. I hope you look forward to it.”
“Show Window: The Queen’s House” premieres on November 29 at 10:30 p.m. KST and will be available with subtitles on Viki.
In the meantime, check out a teaser for the drama with English subtitles below!
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Daily recoveries rise to 251 in Pune Metropolitan Region as Covid cases decline to 208; four more dead | Pune News
The rural areas and Pune municipal limits reported over 100 recoveries each. Among the new additions, the PMC areas added 94 new cases, 79 patients were recorded in the rural and Cantonment areas while Pimpri Chinchwad added 35 new cases.
A report released by district health officer Bhagwan Pawar stated that over 14,100 samples were tested in the region on Saturday. This pushed the tally of sample testing in PMR above 86 lakh. The report further stated that four Covid-19 patients succumbed to the infection in the region on Saturday.
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